9 Studies have identified circulating monocytes as key inflammatory cells in SSc, but which factor drives TIMP-1 is still undefined.
Previous studies have identified circulating miRNAs in serum (Resnick et al, 2009, Chung et al, 2013), exosomes (Taylor and Gercel-Taylor, 2008), and whole blood (Häusler et al, 2010) from ovarian cancer subjects.
14, 15 A recent study has also identified circulating miRNAs as readily accessible blood biomarkers to monitor disease state in multiple sclerosis (MS), a T-cell mediated disorder of the central nervous system.
Our study has identified that circulating microRNAs, notably those of the miR-200 and miR-17 families, are associated with PSA response and/or overall survival in CRPC patients.
Fractionation of adiponectin complexes has identified that circulating levels of HMW adiponectin, or the ratio of HMW to trimer, may be the best indicator of insulin sensitivity and metabolic flexibility [ 2, 3, 6, 20].
Furthermore, we have not identified circulating factors that are associated with peripheral new bone formation in this disease.
Previous work has identified that shock increases circulating tissue plasminogen activator (tPA).
While our study has identified a panel of circulating microRNAs as potential biomarkers of docetaxel response and overall survival, we recognise the limitations of our research.
Therefore, we have identified the circulating levels of IL-1beta that can indicate the evolution of the metastatic processes.
This survey of circulating cytokines has identified elevations in CXCL10 and IL6 as promising markers for leprosy T1R.
