Exact(2)
CBP has highly stringent potential AKT phosphorylation sites at Ser381, Ser1733 and Thr1833, all of which are in CBP's CH1 and CH2/CH3 domains, which interact with ETS1 [98].
There is also a bias toward developing B cell/antibody-targeting drugs for indications outside of transplantation (such as oncology or rheumatology), and the FDA has highly stringent requirements for the approval and labeling of new agents in the transplantation arena.
Similar(6)
To minimize the false positives, we have utilized highly stringent thresholds in the TFBS prediction methodology, and have restricted our analysis to proximal promoters.
In some cases a particular kinase may require its substrate to have a highly stringent recognition site, whereas other kinases may be relatively promiscuous.
While it is clear that we have obtained a highly stringent list of potential pathway partners of p68 and p72, with regard to separable functions (i.e. non-overlapping genes of p68 and p72) we cannot say with confidence as genes generally clustered into the same pathways as for the overlapping list.
Experience has shown that by applying highly stringent criteria for donor selection, the outcome of HSCT is comparable to that obtained when the donor is a compatible sibling [ 6].
This success has been due to using highly stringent mapping parameters for subgenome-specific mapping.
The current safety standards are highly stringent and it has been pointed out that our old antibiotics such as penicillin, which has proven to be a lifesaver on a global scale, would in all likelihood not pass current safety muster.
Related(1)
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