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On the other hand, the 5'-nuclease domain has highest affinity for the flap DNA substrate having no single-stranded gap [28].
One example is dynorphin in human that has highest affinity for the kappa receptor [8] but is located on the same chromosome as the orphanin receptor.
This agent has highest affinity for SSTR-2 and is suitable for imaging on a gamma camera.
MMP-1 shows a preference for the type III form, MMP-8 preferentially degrades type I collagen, and MMP-13 has highest affinity for type II collagen [ 3].
VEGF-A has highest affinity for VEGFR1 [ 44] but the activated complex exhibits relatively weak tyrosine kinase activity and forms a non-productive signalling complex [ 10, 45].
The ER-like binding site has highest affinity for E2 (IC50, 753 nM) but only very weak affinity for T. In addition, BPA exhibits a clear binding (IC50, 24.8 μM).
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First results confirm that calcite has high affinity for Eu3+.
NPs-Fc has high affinity for the FcRn in the acidic endosome compartments, leading to transcytosis and refraining from lysosomal degradation23.
ScASNase1 is classified as an enzyme belonging to bacterial type II, has high affinity for the substrate and exhibits antineoplastic properties.
Caelyx, due to its pegylation, has high affinity for the skin and a very long circulation time.
SOM230 has high affinity for sst1-3 and sst5[27], while KE108 has high affinity for all five sst1-5[28 sst1-5[28
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