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The first stage implements a novel approach, called stochastic subset optimization (SSO), for iteratively identifying a subset of the original design space that has high plausibility of containing the optimal design variables.
The information that these samples provide is then exploited in an iterative approach in SSO to identify a smaller subset of the design space that consists of near-optimal design variables and also that has high plausibility of containing the optimal design.
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This finding has high inherent biological plausibility.
The dose-response relationships were therefore considered having a high plausibility for non-monotonicity.
The application of the Bayesian analysis to the Körblein and Hoffmann (2006) article presented here is an example which overwhelmingly shows the dilemma of relating risk to low doses: Many models may be applied to the data, but the model showing no dose dependence has the highest plausibility based on the measured data.
"The information we currently have shows a high plausibility that poisoning has taken place here," Eckardt said at the press conference.
Out of those 148 reported NMDR relationships, 82 were concluded to have moderate, moderate high, or high plausibility of being non-monotonic.
This interpretation has biological plausibility, because high exposure levels can overwhelm detoxification mechanisms.
The results show an overall high plausibility which supports the consistency of the developed approach.
We preferred this transfer function so that the activation of the network units, viewed as activity of whole neural populations, has an higher biological plausibility (see Heiberg et al. 2013; Nordlie et al. 2010, for an analysis of rate models).
The plausibility assumptions have been estimated in our previous study [ 5] and the true uncertainty based on current knowledge would probably show higher plausibility and thus have lower importance in this analysis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com