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Although therapy with intraocular drugs inhibiting vascular endothelial growth factor has had a substantial effect on reducing visual impairment for wet AMD [ 2], no effective therapy is available for dry AMD.
The film has had a substantial effect on pop culture a still from the film was used for the cover of the Smiths 1983 single "This Charming Man," the Pet Shop Boys sample sound bytes from the film in their song "DJ Culture," and Empire magazine called out the film in their list of "The 100 Best Films Of World Cinema" in 2010.
Influenza has had a substantial effect worldwide.
The introduction of combination antiretroviral therapy (cART) for human immunodeficiency virus (HIV) has had a substantial effect on morbidity and mortality in the HIV-infected population.
Since then, TB treatment has become widely available, and the emergence of HIV has had a substantial effect on TB incidence (4, 5 ).
The announcement of the withdrawal of co-proxamol in the UK has had a substantial effect on prescribing and on deaths from poisoning in England and Wales, particularly suicides.
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The candidates' ads have had a substantial effect.
He added, "We did our best, and we don't know if anything that happened would have had a substantial effect on the election".
Prosecutor Alison Morgan said the messages had had a "substantial" effect on Creasy, who felt "increasing concern that individuals were seeking not only to cause her distress but also to cause her real harm, which led her to fear for her own safety".
But, many members of this population do not self-identify as white and recent historical events may have had a substantial effect on racial self-identity.
It appears that the data differences between the survey training set and the DLS-100 set had very little effect on the quality of the machine learning predictions and therefore are unlikely to have had a substantial effect on the human predictions.
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