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Most of tick control is routinely accomplished by acaricides, however long term treatment has generated resistant strains.
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The long-term use of bactericidal and bacteriostatic antibiotics has generated multidrug resistant pathogens, such as, Staphylococcus aureus (Levy and Marshall 2004; Cegelski et al. 2008), and resulted in a public health crisis.
However, artificial selection using B. thuringiensis formulations or Cry proteins under laboratory conditions has generated B. thuringiensis-resistant colonies in many more insect species [5].
In addition to this low efficacy, reemergence of the disease caused by the appearance of the acquired immunodeficiency syndrome (AIDS) and multidrug-resistant (MDR) strains has generated requirements for a new and more efficient vaccine against TB [ 7].
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has generated considerable concern among medical and public health professionals.
The rapid emergence of multiple drug resistant strains of pathogens to current antimicrobial agents has generated an urgent intensive search for new antibiotics from medicinal plants.
Emergence of multiple drug resistant bacterial strains due to indiscriminate use of antibiotics has generated a keen interest in the discovery of effective plants derived drugs [ 18].
Moreover, emergence of multiple drug resistant strains of microorganisms due to indiscriminate use of antibiotics to treat infectious diseases has generated a renewed interest in herbal medicine [ 3].
Already, his trip has generated much excitement.
The company has generated some dedicated customers.
In this study we have sequentially generated resistant strains to first rifampicin and then rifabutin.
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