The reaction of the Bush administration - Afghanistan, Iraq, Guantánamo, terror clampdowns within America - have generated profound fears about the president's intentions.
Using the approaches outlined above, biologists have made a number of recent discoveries that highlight the ways in which random mutation and artificial selection have generated profound changes in domesticated animals and plants.
A team of physicists based at the University of Rome has generated both intense excitement and profound skepticism among scientists around the world by presenting evidence that they may have detected a heavy particle that could solve a 70-year-old mystery in astronomy and lead to a conceptual breakthrough in physics.
As a signal of the profound unease that his candidacy has generated among senior Republicans, the speaker of the House, Paul Ryan, effectively dumped Trump, telling congressional colleagues that he would neither defend his party's nominee nor campaign with him.
There is no doubt that, thanks to the development of omics technologies, these efforts have generated a wealth of new knowledge that has led to profound revisions to biological thinking, our understanding of how life functions and diseases occur.
"I had generated laughter.
It generates profound experience as both giver and receiver.
The knowledge that treatments will be withdrawn generates profound emotional distress in the family members.
Through collective action, we are confident that our efforts will generate profound results.
The classical U lineage genes in cyprinids, salmonids and medaka display profound polymorphism which in part has been generated through point mutations.
