These studies have further delineated the role of CFTR in airway gland secretion and identified it as a potential drugable target for secretory diarrheas such as cholera.
Recent studies have elucidated new substrates for Sirt1 that are involved in metabolic regulation, and have further delineated Sirt1's functional associations with other metabolic regulators like AMP-activated kinase (AMPK).
Subsequent collaborative studies have further delineated various reproductive, metabolic, and physiological characteristics of this valuable and useful animal model.
More recent studies on PTPμ have further delineated this pathway: PTPμ-mediated neurite extension in retinal neurons is also dependent on PKCδ [ 43] and Cdc42 [ 44] activity.
Recently, Hashimoto et al (2001) have further delineated the involvement of 3q gains in HNSCC tumorigenesis by demonstrating a correlation between amplification, as opposed to low level gain, of 3q26 qter and tumour progression.
Here, we have further delineated a truly bimodal efficacy of G-CSF both for acute effects on infarct size, as well as on chronic enhancement of post-stroke recovery.
Recent studies have further delineated the multiple functions of fakA as an important regulator of virulence factors [ 26] and as a fatty acid kinase responsible for host fatty acid incorporation by S. aureus [ 25].
Targeted inactivation of PTH and the Ca-sensing receptor have further delineated the existence of calcium-stimulated FGF23 production independent of other variables, and demonstrated that calcium-mediated increases in FGF23 levels required a given threshold level of serum phosphorus concentration [ 22].
Additionally, robust laboratory and animal data have further delineated the roles of hemolysis-related decreased nitric oxide bioavailability (Reiter et al, 2002), ischaemia-reperfusion injury (Kaul & Hebbel, 2000), and endothelial activation (Embury et al, 2004; Belcher et al, 2005) in exacerbating the microvessel occlusive events of SCD.
