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We predict that this domain has functional significance and may mediate some of the neural functions already indicated for Sho.
Our results confirm the presence of a novel F genome-specific ORF of significant length (>375 nt), located in VD1, that most likely has functional significance in marine mussels (Mytilus spp).
The A>G substitution has functional significance, such that the long allele with the G substitution (Lg) functions similarly to the short allele (i.e., reduced transcription efficiency and decreased expression) [ 36- 38].
The region they comprise displays marked inter-individual variability in sulcal and gyral architecture, and although recent evidence suggests that this variability has functional significance, it is often ignored in automated and region-of-interest (ROI) morphometric investigations.
This novel type of mutually induced signalling circuits probably has functional significance in vivo [19], [30].
Such conservation would not be expected unless the repeat region has functional significance at the protein level.
Similar(20)
Does a statistically-significant change in expression have functional significance?
This conservation may have functional significance for PfEMP1 folding, transport, or binding activity.
A number of observations suggest that PAS-induced excitability changes may have functional significance.
How often in our day-to-day lives does maleness or femaleness have functional significance?
This fact may have functional significance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com