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Whether this type of transcriptional fusion has functional relevance is currently unknown as are the functions of slr0199 and sll1477.
The RNAMute package allows a comprehensive categorization, given an RNA sequence that has functional relevance, by exploring the patterns of all single-point mutants.
These results suggest that the physical interaction between PKCη and ATP1A1 has functional relevance in regulation of TJ permeability.
Yet, the Fis1-TOM6 fusion protein was targeted to and stabilized the TOM complex in Δtom6 yeast strains, leaving the possibility that the TA domain of Tom6 has functional relevance [18].
Moreover, it was suggested that the recycling pathway regulated by Rab11 has functional relevance in aSyn secretion.
IL18 has functional relevance to OX40L (16), a known SLE risk locus, where it has been shown to induce OX40L on stimulated T cells and dendritic cells (16).
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Interestingly, alternatively spliced E6 transcripts have so far only been described for HR-HPVs but not for LR-HPVs (Hernandez-Lopez and Graham, 2012), implying that this region may have functional relevance on biological processes of HR-HPV carcinogenesis.
In this study, we hypothesized that IL-27 could induce the expression of novel miRNAs in macrophages which may have functional relevance in terms of anti-viral activity and primary monocytes were differentiated into macrophages using either M-CSF (M-Mac) or a combination of M-CSF and IL-27 (I-Mac) for seven days.
This indicates that these novel miRNAs may have functional relevance in the pathogenesis of ALL.
GO terms that may have functional relevance for selection in Thoroughbred are listed in Table 2.
Only some of the interactions have been confirmed and/or shown to have functional relevance at a cellular level [10].
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