Sentence examples for has formally demonstrated from inspiring English sources
The PALETTE trial has formally demonstrated the benefit of treating patients with anti-angiogenic agent over placebo in terms of PFS in a Phase III setting (Table 2) [ 18, 19].
Rituximab is thus far the only agent that has formally demonstrated significant slowing of structural joint damage in RA patients with an inadequate response to or who are intolerant of TNF inhibitors [ 49].
We have formally demonstrated this for AP-1 IPs (Figures 2&3, Tables 1&2).
Here we have formally demonstrated that when CTL-mediated killing occurs early during the intracellular eclipse phase it can control HIV replication very efficiently, while remaining consistent with current observations on the up-slopes and down-slopes of the viral load observed during CD8+ T cell depletion experiments and antiretroviral treatment.
Firstly, we have formally demonstrated the presence of the signalling complex described to mediate the rapid action of oestrogen in breast cancer within human breast tissues.
Several lines of evidence have linked these cohesion establishment factors to the DNA replication fork, though their specific requirement for cohesion establishment during S-phase, as opposed to cohesin loading onto chromosomes or maintaining sister chromatid cohesion, has formally been demonstrated only for the Ctf18 complex and Csm3 (Xu et al. 2007).
However, not all DNA repair systems are coupled to transcription, and to date NER (the pathway involved in the reparation of these lesions) is the only pathway for which transcription coupled repair has been formally demonstrated.
It has been formally demonstrated that Asian and Caucasian gastric cancers differ in terms of epidemiology, diagnosis, treatment and prognosis.
However, flavanols are one of the few bioactives known today, for which causality between intake and an improvement in arterial function has been formally demonstrated.
While we observed viral nucleic acid sequences in the samples, we have not formally demonstrated that these viruses are replicating.
Although we have not formally demonstrated that zinc uptake is required for zinc to be toxic to bacteria, it is worth noting that bacterial death correlates with increased cytosolic free zinc in our experiments.
