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The OPQOL has excellent applicability to cognitively normal subjects [ 19], and was shown here to be applicable to people suffering from mild to moderate dementia.
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Moreover, this questionnaire was recently shown not only to have excellent applicability to cognitively normal subjects but also to be applicable to people suffering from mild or moderate dementia in two studies addressing the association of QOL with both frailty status and living status in an older population referred to the same geriatric service in Italy [ 10, 31].
Analyses were adjusted for major confounders, including comorbidity and concomitant drug treatment, and the findings probably have excellent applicability to current clinical practice in similar settings around the world.
TE analysis has excellent inter- and intraassay agreements, but its applicability (80%) is not as good as that of serum biomarkers [ 12].
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