Sentence examples for has established roles from inspiring English sources
Cholesterol also has established roles in gallbladder disease [ 21, 32] and modifies other gastrointestinal functions.
Dlk1 has established roles in influencing proliferation and differentiation of several tissues, including adipose [ 50, 72– 74] and skeletal muscle [ 55].
Although CGRP has established roles in central nociceptive transmission and neurogenic inflammation in peripheral tissues (17, 18), its role in modulating peripheral nociception is poorly understood.
HIF has established roles in the response to hypoxia (Moniz et al., 2014; Semenza, 2011), and several studies using cell-specific HIF-α knockout have established a role for HIFs in the immune response.
Dual-energy computed tomography (DECT) has established roles in cardiology as a means to image calcification within coronary artery plaques [ 30] and in renal medicine for the identification of uric acid calculi [ 31].
Experimental work with this model has established roles for B-cell-secreted autoantigenicomplexescomplexes in activating alternative complement, its subsequent association with C5aR and FcgRIII-mediated cell activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction.
Remarkably, HOXD3 gene, adjacent to HOXD-AS1 locus, has established role in promoting metastatic potential of lung cancer cells [ 45].
IL-1α (and IL-1β to a lesser extent) induces the production of CXCL1 and CXCL2, chemokines that have established roles in neutrophilic chemotaxis via CXCR1 and CXCR250,51,52.
PREX1 promotes the motility and invasion of glioblastoma cells, promoting Rac-mediated activation of p21-associated kinases and atypical PKC, which have established roles in cell motility.
