A chapter of Phi Beta Kappa survived at Dartmouth, but by the 1830s had established its role as a strictly literary society by dropping requirements of secrecy for membership and activities.
Various successful instances of target identification, drug discovery, and disease network reconstruction using humanized yeast models have established its role as a model system for studying human disorders.
In the last half century, though, the rebuttal has established its own role as if under common law, sometimes used by the opposition to showcase a rising star, sometimes to sound a thematic epilogue, and sometimes simply because political speech abhors a vacuum.
As a drummer, he represented the apparent loosening of the ties with the rhythms that had characterised jazz since its earliest days, and which had established its original role as a music for dancing.
By the 20th century, the exchange had established its pre-eminent role.
It is possible that the respiratory consequences of prenatal exposure to phthalates mimic what has been observed following prenatal exposure to cigarette smoke, where several large cohort studies have essentially established its role in recurrent wheeze in very young children (Magnusson et al. 2005).
While the role of SDF-1α in the metastatic spread in solid tumors has been clearly established, its role in activation of RhoGTPases has only been described in the context of multiple myeloma where SDF-1α binding to its receptor CXCR4 induces chemotaxis and motility through RhoA activation [ 23].
Since it was first described in 2006 for the detection of cholesteatoma [1, 2], non-echoplanar diffusion weighted magnetic resonance imaging (DWI) has now firmly established its role as the imaging modality of choice in detecting post-operative cholesteatoma [3, 4, 5, 6, 7].
Although the impact of proinflammatory cytokines under septic conditions has been well established, its role after severe traumatic injury is not as well delineated.
