Sentence examples for has dramatically impaired from inspiring English sources

The reliance of the PTEN effects upon phosphatase activity was investigated by expression of the active-site mutants PTEN C124S, which lacks all detectable phosphatase activity, and PTEN G129E, which has dramatically impaired lipid phosphatase activity but retains full protein phosphatase activity [22].

Another difference between the two experiments is that no insertional mutant strains had dramatically impaired growth as observed for the chemical mutant set (Fig.  3).

The ability of the modifier alleles to restore dosage compensation to the X nearly as well as wild-type MSL1 demonstrates that such complexes have essentially normal chromatin remodelling activity, despite having dramatically impaired ability to spread locally.

In addition, these cells have a dramatically impaired ability to metabolize TPZ to its two-electron reduction product, SR4317, under hypoxic conditions when compared to wild-type cells.

This has dramatically changed, however.

The widespread use of antiretroviral therapy has dramatically improved life quality and expectancy of infected individuals, but limitations of currently available drug regimens and dosage forms, alongside with the extraordinary adapting capacity of the virus, have impaired further success.

It has dramatically failed.

Normal mice have spontaneously high levels of alternation, whereas hippocampal-lesioned mice are dramatically impaired.

Moreover, humoral immune responses in these mice are dramatically impaired.

Consequently, migration and invasion were also dramatically impaired.

Proliferation of Bax/Bcl-w transformants was less dramatically impaired.