Sentence examples for has downregulated from inspiring English sources

At 30  μM, BA could not downregulate any of the three proteins; however, at this concentration HBA has downregulated all the three proteins significantly.

As a consequence free receptor is still available when I-Smad has downregulated the response and ligand can still trigger a further response.

Our results corroborate these data [ 25], showing that the NKp44-negative population, which has downregulated DAP12, is more cytotoxic than the NKp44-positive population.

The PARP inhibitor olaparib has demonstrated pathological response in breast cancer patients carrying BRCA1/2 mutations, and it is reasonable to ask whether it might have an effect in sporadic TN disease, much of which has downregulated BRCA1 expression.

Most cervical cancers have downregulated the expression of at least one HLA class I antigen, whereas class II expression is incresaed in infected epithelium.

(Three patients remain in complete remission at the time of publication six, nine and 21 months after receiving the CD22-targeted therapy). Most of those who relapsed had leukemia cells that had downregulated the expression of CD22 on their surfaces.

Thus, the reduced endocrine and sleep response to metyrapone in PTSD suggests either that PTSD subjects have downregulated central responses to CRF or that PTSD subjects had less of a CRF response because of less adrenal suppression of cortisol.

Fig. 3C shows the average percentages of TNF producing SP P14-CD8+ donor thymocytes and splenic T cells that had downregulated their CD62L expression under the indicated conditions.

Interestingly, the majority of P14 transferred cells had downregulated the expression levels of CD127 (Fig. 5), which was even more pronounced in the early transferred group.

Considering the significantly higher serum corticosterone level and extreme low brain BDNF levels in the F-Ex rats, we speculate that corticosterone released during the forced exercise had downregulated the brain BDNF expression.

These results suggest that RA may indeed have downregulated the genes involved in adhesion and migration.