Four chemically unrelated CGRP receptor (CGRP-R) antagonists (olcegepant, telcagepant, MK-3207 and BI 44370 TA) have displayed efficacy in the treatment of migraine [192].
Pyronaridine has demonstrated activity against falciparum parasites resistant to other antimalarials, and PA has displayed consistently high efficacy in multiple large clinical trials (2).
But so far he has displayed moderation.
In early trials, antibodies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) or the programmed death 1 (PD-1) signaling pathway have displayed significant efficacy with minimal toxicity in patients with relapsed and refractory hematological neoplasms.
Lapatinib plus vinorelbine offers an effective treatment option for patients with HER2-overexpressing MBC, having displayed comparable efficacy and tolerability rates to lapatinib plus capecitabine.
Among the chemical compounds that have been attempted for CHIKV, some of the well-known broad-spectrum antivirals like chloroquine, ribavirin, and interferon, which have displayed some efficacy in humans, may prove to be promising.
It has also displayed efficacy in the prevention of postoperative thrombophlebitis [ 32], management of balance disorders of central origin, Parkinson's disease, Leukoaraiosis, and benign prostatic hyperplasia [ 3].
Both CDPPB (20, 21) and ADX-47273 (24− 26) have displayed in vivo efficacy in behavioral models.
Despite the fact that active and passive immunisation against amyloid-β (Aβ) has been shown to clear or prevent Aβ brain plaques and improve cognitive performance in numerous mouse model studies [ 8], large-scale trials of several immunotherapeutics targeting Aβ have displayed little or no cognitive efficacy [ 6].
Both campaigns have engaged in sound bites and simplifications of these major policy differences, but in explaining, defending and attacking each other, they have displayed clear distinctions in their beliefs in the efficacy of diplomacy.
