Because all enrolled patients had established dyslipidemia (low HDL-C levels) and because other trials had demonstrated substantially improved outcomes with XZK therapy, it was deemed ethically unacceptable to randomize patients to placebo or no treatment.
A large variety of animal models of soft tissue flap ischaemia have demonstrated the ability of HBO to preserve acutely ischaemic tissue and improve flap survival, while others have demonstrated substantially accelerated and improved quality of healing of muscle, tendon, peripheral nerve and bone.
None of the inosine-containing variants demonstrated substantially improved activity compared to the corresponding mismatched variant (Fig. 6b).
In comparison, the 1987 ACR classification criteria ROC-curves in this cohort had an AUC of 0.72 for diagnosis (p=0.00451), and 0.65 for DMARD start (p=0.00145), demonstrating substantially improved performance of the 2010 criteria in early arthritis patients.
No adjuvant therapy has demonstrated improved survival.
In conclusion, although the primary end point has not been met in this randomised phase II trial, the study has demonstrated that the addition of sunitinib can substantially improve response rate in metastatic gastric cancer in a second-line setting.
Nonetheless, a number of organizations have demonstrated that quality can be substantially improved in a variety of ways if IT use is increased in ways that improve care.
This study represents an important first step – we have demonstrated that Internet education can substantially improve clinicians' knowledge and confidence regardless of the delivery strategy; next, innovative, cost-effective strategies to improve behavior and clinical outcomes need to be developed and evaluated.
For instance, disruption of ethanol synthesis has been demonstrated to substantially improve flux through the 1, 3-PD biosynthetic pathway in K. pneumoniae (Zhang et al. 2006).
On the contrary, the seismic performance of CBF has been demonstrated to substantially improve when the design is specifically addressed to obtain resistant ultimate mechanisms characterized by the yielding of diagonals.
Xylan removal or deacetylation of the xylan backbone has been demonstrated to substantially improve the biodegradability of many types of lignocellulosic biomass [ 22- 26].
