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Recent work has demonstrated substantial differences in the DNAm signature across different leukocyte subtypes [ 13- 15] and also differences in white blood cell proportions by EOC case-control status [ 41- 43].
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Recent studies have demonstrated substantial differences in genomic alterations between mutated and unmutated IGHV subgroups, which reflect distinct molecular pathways and mutagenic mechanisms in the pathogenesis of the disease.
Second, previous studies have demonstrated substantial individual differences in telomere attrition rates (e.g. [ 11, 15]).
Recent studies by our group and others have demonstrated substantial molecular differences between adult and paediatric HGG [ 35].
Previous studies have demonstrated substantial sex differences in kidney messenger RNA (mRNA) expression in rodents [ 32, 33], which may influence sexually dimorphic adverse events.
A number of studies examining the neurochemical differences in the Flinders model have demonstrated substantial changes in both their cholinergic and serotonergic function in the FSL compared to the FRL rats [7], [26] [28].
Mice carrying FVII+/− genotype have demonstrated substantial phenotypic changes such as prolonged PT in plasma.
Bilingual education programs, the report concludes, "have demonstrated substantial effectiveness in developing the English language proficiency" of immigrants.
The artist is expected to have demonstrated substantial engagement with original source materials during the fellowship.
However, clinical trials have demonstrated substantial obstacles to their use, such as immunogenicity and inflammatory potential[26].
These questions have demonstrated substantial reliability.
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