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Despite a substantial investment in trials testing dozens of therapeutics in humans, however, to date none has demonstrated robust efficacy.
This strategy has demonstrated robust RNAi-mediated gene silencing in liver after subcutaneous administration across species, including human.
TAS-106 is a novel nucleoside analog that inhibits RNA polymerases I, II and II and has demonstrated robust antitumor activity in a wide range of models of human cancer in preclinical studies.
The IWQOL-Lite has demonstrated robust psychometric properties in obese persons with and without diabetes [ 20].
The LAS, a self-report scale designed to measure sense of control during childbirth has demonstrated robust psychometric properties with an internal reliability coefficient of 0.97 and evidence of construct validity demonstrated through factor analysis and dual scaling procedures [ 12].
Sulfite pretreatment to overcome recalcitrance of lignocelluloses (SPORL) is a relatively new process, but has demonstrated robust performance for sugar and biofuel production from woody biomass in terms of yield and energy efficiency.
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The CAPRA score and its derivatives have demonstrated robust clinical discrimination in a decade of validation studies.
Previous studies have demonstrated robust interference, as evidenced by slower RTs, when the motion used to respond mismatches that implied in a sentence.
However, given that we have demonstrated robust changes in key follicular regulatory factors, we suggest that our methods have not limited our results.
Specifically, only the dependent variables which have demonstrated robust 'type of grasp' effects in previous research [e.g., 10, 22] are considered.
Biologics have demonstrated robust efficacy in PsA to date [ 2].
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