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Related research has demonstrated persistent ANS impairment in cancer survivors, with and without advanced disease [ 8, 32, 43, 46, 47].
It is noteworthy that a large study using a transient period of continuous subcutaneous insulin infusion or multiple daily insulin injections in newly diagnosed patients with type 2 diabetes has demonstrated persistent improvements in the acute insulin response to glucose even 1 year after the short-term intervention (13).
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Studies have demonstrated persistent hyperexcitability of dorsal horn neurons which may provide a substrate for CNP.
Thus, we have demonstrated persistent, and inducible in vivo expression of a gene from a liver-specific Tet-On inducible construct delivered via an AAV vector and proved to be an efficient tool for treating liver cancer.
Previous studies have demonstrated persistent coronary arterial dysfunction in patients with persistent and regressed coronary aneurysm [ 3- 5].
Importantly, studies have demonstrated persistent elevations in LPS levels as measured by the EAA up to 3 days after initial development of severe sepsis.
A number of studies have demonstrated persistent, low level HIV-1 replication in patients receiving oral highly active antiretroviral therapy (HAART) that renders them aviremic [ 32- 34].
Further, our analysis is limited in that we have not performed gene expression studies, which have demonstrated persistent gene expression changes consistent with lobule differentiation with parity [ 45, 53, 54].
A small number of studies have demonstrated persistent risks in early term gestation (defined as 37 to 38 completed weeks) casting doubt on the practice of considering all infants born at 37 weeks GA as a homogenous term group.
Zebrafish models of diabetic wound healing have demonstrated persistent, hyperglycemia-induced gene expression and DNA methylation patterns that are associated with impaired healing and tissue regeneration in response to a wounding insult.
While Ilicki and Larsson reported that Swedish children with congenital hypothyroidism who were diagnosed by neonatal screen and were given early treatment displayed average development as compared to the normal population [ 4], other studies have demonstrated persistent deficits.
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