Sentence examples for has demonstrated dramatic from inspiring English sources

The recent FDA approvals of crizotinib, an ALK kinase inhibitor that has yielded significant clinical benefit in ALK-translocated lung cancers, and vemurafenib, a BRAF-selective kinase inhibitor that has demonstrated dramatic clinical efficacy in BRAF mutant melanoma patients, define the new landscape for tailored cancer drug therapy.

Our previous analysis using this model has demonstrated dramatic effects on embryogenesis upon reduction of htt expression (18).

Stretch imposed on alveolar epithelial cells has demonstrated dramatic increases in IL-8 release as well as IL-8 gene transcription in vitro [ 13].

Whole-genome gene expression analysis of wine yeast strains during fermentation under wine-making conditions has demonstrated dramatic expression changes in ∼40% of the genome, including upregulation of stress response, energy production, and surprisingly, glucose repressed genes (Backhus et al. 2001; Marks et al. 2008; Perez-Ortin et al. 2002; Rossignol et al. 2003; Varela et al. 2005).

However, experimental studies with the thiol cysteamine and its disulfide cystamine have demonstrated dramatic cytoprotection in experimental models where antioxidants provide only minor protection.

Great Lakes lake whitefish (Coregonus clupeaformis) have demonstrated dramatic changes in growth and life history traits since the appearance of dreissenid mussels in the Great Lakes, but the role of habitat occupancy in driving these changes is poorly understood.

"Gracefully" was very much on my mind, since the previous flight, five days earlier, had demonstrated dramatic rolling.

While researchers have demonstrated dramatic improvements in many bariatric patients' metabolic function in the short term, the durability of those improvements has been unclear.

Microarray analyses in yeast and human cells have demonstrated dramatic effects of rapamycin on gene expression [6] [10].

Somatostatin analogs and especially mTOR inhibitors have demonstrated dramatic effects in controlling hypoglycemia and reducing tumor burden [115], [116].

Recent studies have demonstrated dramatic increases in the use of, and expenditure on, CAM in the United States, Canada, Australia and European countries [ 5- 8].