Ample literature has demonstrated dysfunction of regulatory T cells in SLE, with SLE regulatory T cells being inefficient suppressors of inflammation and T-cell proliferation [ 85, 86].
Ample evidence has demonstrated that prolonged exposure to elevated glucose concentrations induces a series of glucotoxic alterations in β cells, such as oxidative stress, endoplasmic reticulum (ER) stress and protein glycation, leading to irreversible β-cell dysfunction and eventual apoptosis.
Ample research has demonstrated the positive association between trust and individual health outcomes; it is implicit and integral to healthcare relationships. 4 Several studies have indicated that greater trust is associated with greater adherence to treatment and better self management of chronic illnesses such as diabetes.
However, ample clinical experience has demonstrated that few clinicians would consider prescribing anticoagulants at such low probability of PE [ 18].
Ample studies have demonstrated the correlations between the interfacial area and saturation (Pan et al. 2007; Gladkikh and Bryant 2003; Oostrom et al. 2001; Kawanishi and Hayashi 1998; Bradford and Leij 1997; Kim et al. 1997; Karkare and Fort 1996), capillary pressure (Raeesi and Piri 2009; Helland and Skjæveland 2007; Held and Celia 2001; Reeves and Celia 1996), and REV (Culligan et al. 2004).
Ample studies have demonstrated the implication of histone hyperacetylation in gene transcription but also in silencing gene expression of others [ 27, 44, 45].
Ample studies have demonstrated the benefit of HO-1 in a variety of pathological states including vascular injury, hypoxic lung disease and cardiac diseases [ 13- 15].
Ample studies have demonstrated that, as a consequence of HMG-CoA reductase inhibition, statins block the production of farnesyl diphosphate (FPP), serving as substrate for, among others, the synthesis of the side chain of ubiquinone.
Now you have demonstrated.
This was confirmed on evaluation of bone marrow biopsy specimens obtained at the platelet nadir, which demonstrated ample numbers of megakaryoctyes, most of which had actually lost their characteristic appearance, and failed to demonstrate evidence of terminal budding.
