In addition, historical factors including past changes in the direction and sense of ocean currents, vicariant events caused by both climatic and eustatic sea level changes [ 7, 9, 19], as well as climate-associated periodical extinctions and recolonizations [ 20] have also decisively contributed to shaping present-day population genetic differentiation and geographic distribution.
Nevertheless, it is unlikely that serum estrogen decisively contributed to the differences in HDL-2 observed in the present study, as it has been demonstrated to be unaltered in RA women [ 39].
Furthermore, the local tumour microenvironment has been shown to decisively contribute to cancer growth, metastasis, and progression to resistance (Bissell et al. 2002; Wiseman and Werb 2002).
The cases described in this paper are mainly initiatives aiming to change social practices, as such they are not social innovations yet, but they have the potential to have a broad impact changing social practices (within their respective target groups)—i.e. to become, or decisively contribute to, social innovations.
In recent years, it has been reported that components of PI3K/AKT and MEK/ERK signaling pathways are frequently altered in human tumors, which decisively contribute to the clinic drug resistance.
The reconstruction of acquired facial defects and deformity resulting from trauma, burns, and tumor resection has always been a great challenge for surgeons as the head and neck region provides complex anatomy and essential functions decisively contributing to each patient's quality of life.
We believe that cloud-assisted architecture can decisively contribute to event monitoring performance improvement.
Firms' strategic movements can decisively contribute to the definition of the DD.
This can decisively contribute to not unnecessarily putting efforts in approaches which are subsequently rejected by the competent authorities.
There is a suggestion that high concentrations of GSH, GSH-Px and GSTpi, independent of other intracellular alterations, do not decisively contribute to MDR [ 19, 20].
