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Computer scientists have an acronym for it: GIGO, or Garbage In, Garbage Out.The weakness of the critics' case and it is a major weakness is that no one has convincingly identified a giant systematic error.
Hence, even without the availability of the corresponding funnel plot for the FDA data (fig 1A), a contour enhanced funnel plot has convincingly identified publication biases as a major problem for the journal data.
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Although French psychiatrists in the nineteenth century had convincingly identified the forerunner of our bipolar disorder [Falret's "folie circulaire" (1851) and Baillager's "folie à double forme" (1854 ], other clinicians and scientists continued to regard melancholia and mania as separate conditions.
To date, few studies have convincingly identified alcohol use as a significant risk factor for PD.
Genome-wide association studies (GWAS) have also been used to dissect the genetics of endometrial cancer and so far have convincingly identified one associated SNP, rs4430796, on chromosome 17q close to the HNF1B gene (Spurdle et al. 2011; Setiawan et al. 2012; Painter et al. 2014).
To date, GWAS for endometrial cancer have convincingly identified evidence for endometrial cancer risk association at the HNF1B locus (Spurdle et al. 2011; Setiawan et al. 2012; Painter et al. 2014), the risk allele of which (rs4430796A) maps to a region that has also been associated with the risk of ovarian and prostate cancers (Gudmundsson et al. 2007; Shen et al. 2013; Thomas et al. 2008).
It has also been suggested that these alternative isoforms might interact with unique ligands, but to date, no isoform-specific ligand has been convincingly identified.
The heritability of B cell chronic lymphocytic leukemia (CLL) is relatively high; however, no predisposing mutation has been convincingly identified.
Unfortunately this study, involving almost 1000 sheep that were extensively phenotyped and genotyped, has only convincingly identified one QTL, on chromosome 8, for parasite resistance.
However, no such factor has been convincingly identified, biochemically purified and tested to verify its role according to Koch's postulates for causation.
However, the identification of causal functional DNA polymorphisms underlying QTL has remained problematic, with such variations having been convincingly identified for no more than 9 QTL [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com