Additionally, since the cetuximab and IMC-A12 treatments were limited to only three times at 3-d intervals, differential up-regulation of EGFR or IGF-1R after the termination of treatments may have contributed to accelerated tumor growth.
Furthermore, we discuss these results in the context of populations of small effective sizes under extreme stress conditions under which retrotransposons (re)activation could have contributed to accelerated speciation.The major cluster of ribosomal RNA genes is expressed as the 45S transcriptional unit.
This tool has provided district managers with practical means of demonstrating the potential impact of investing in CHPS on health outcomes and may have contributed to accelerating the expansion of investment in CHPS between 2010 and 2012.
USAID's long and strategic investments in the field through a variety of partners in government, academia, non-governmental organizations and commercial entities (e.g., Walter Reed Army Institute of Research, Naval Medical Research Center and the Malaria Vaccine Initiative at PATH) have contributed to accelerating progress toward the goal of an efficacious and cost-effective vaccine.
Down-regulated Cry1 expression in cells was found to cause accelerated growth rate in primary fibroblasts (Destici et al. 2011), so it is probable that the HMF-induced Cry down-regulation has contributed to the accelerated NS growth.
It had better be, because the scramble for position in the pan-European market has contributed to an accelerated pace of mergers and acquisitions.
Investor concern that inflation, which erodes the value of a bond's fixed payments, will accelerate has contributed to the worst two-month period for government debt in at least 20 years.
"We have pulled forward our reorganisation plan for our European operations, which has contributed to further trading disruption but which accelerates our overall plan".
Sea level rise has accelerated, climate change has contributed to devastating extreme storms, heatwaves, and droughts (both in the U.S. and abroad), and Arctic sea ice is vanishing fast.
We further estimated the evolutionary rates in branches and clades emerging from such duplications to test whether accelerated evolution of paralogs has contributed to the evolution of this metabolic pathway.
