In the postgenomic era, computer-aided drug design (CADD) has considerably extended its range of applications, spanning almost all stages in the drug discovery pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials.
Furthermore, the development within some health care systems of various policymaking structures that act as receptor bodies for research, such as the National Institute for Health and Clinical Excellence NICEE) in the UK, has considerably extended the opportunities for research to be used in policymaking, and especially in clinical policymaking [ 6].
Through accident and design and the inability of the princes to collaborate effectively, Louis had succeeded in countering the threat of a princely constitution and had considerably extended the royal domain.
In recent years, CubeSats have considerably extended their range of possible applications, from a low cost means to train students and young researchers in space related activities up to possible complementary solutions to larger missions.
sifiability, a scientific theory T r is only aban Following Popper, others such as Kuhn, with doned if its place is taken by another theory T2 his paradigm theory, have considerably extended which has the following three characteristics: 1 the range of thought over what is scientific and T 2 has more empirical content than TI; the new what is not.
10 These databases and observational studies have considerably extended the knowledge of GHD and its treatment, but many issues remain unresolved.
Notably, about 10% of treated mutants had considerably extended lifetimes, which were threefold longer than untreated mutants and comparable to the maximal lifespan of control WCS flies.
Most studies have collected data close to the time of diagnosis and primary treatment, when the emotional turmoil in the family members reaches its peak level, while we have considerably extended time intervals between cancer diagnosis and the surveys.
In this study, we have considerably extended previous knowledge on the expression of 13 histone deacetylases in tissues (spinal cord and muscle) from mice carrying two different ALS-linked SOD1 mutations (G93A-SOD1 and G86R-SOD1).
