The congenic model (WKY.L Crgn2) has been comprehensively tested in previous studies where they have shown that the JunD expression levels are significantly higher in WKY when compared with the congenic [ 4] and by performing TransAM assay it has been shown that the canonical binding of AP-1 is significantly greater in WKY compared to WKY.L Crgn2[ 9].
Further, the larval odor receptor repertoire has been comprehensively tested in terms of electrophysiological responsiveness to odors in the "empty neuron" system (Dobritsa et al., 2003; Kreher et al., 2008).
To our knowledge, the only core autistic-like symptoms that have been comprehensively tested in Fmr1-KO mice have been deficits in social interaction [24], [25], [26], [27], [28], [29].
We have previously partially examined the role of Or42a and Or42b in setting peak responses to ethyl acetate, but have not comprehensively tested these responses across a broad range of odor concentrations (Kreher et al., 2008).
I presumed that the field these systems had been comprehensively tested in was in and around the Gaza strip, but as soon as I raised the topic a burly security guard ushered me away.
Given that grade has been shown by multiple independent groups to be prognostic and that the levels of inter-observer agreement have increased with the adoption of NGS, it is rather surprising that clinical practice has changed with molecular tests that have not been as comprehensively tested but has not changed with NGS.
Another technology employed in recent years to remove cyanotoxins from aqueous solutions is carbon nanotubes, which have a high adsorption capacity compared to activated charcoal and other conventional adsorbents, such as mineral clays [13], but this technology has not been comprehensively tested for its toxicology effects.
While promising, their approach has not been comprehensively tested and needs background knowledge about the structure of embryos.
