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This confirms that the E4.5 gonads are still undifferentiated, whereas at E6 the differentiation process has commenced, reflected by down-regulation of genes required for the formation of the undifferentiated gonad and up-regulation of sex-differentiation genes.> -wrap-foot> Thexpressionof of known or implicated sex genes in the female and male gonads, at E4.5 and E6.
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