Sentence examples for has central roles from inspiring English sources

β-catenin is a key effector of the Wnt signalling pathway that has central roles not only in embryogenesis and tissue homeostasis but also in tumorigenesis (for review, see [31]).

As is well known, Mg2+ has central roles in chlorophyll structure, as an enzyme cofactor and in exporting photosynthate (Marschner and Cakmak, 1989).

This is the ncRNA that, apart from SNORD62 (which also has central roles in the global and controls' networks), shows the highest outdegree in the disease-specific network.

DOI: http://dx.doi.org/10.7554/eLife.03970.002 Endocytosis has central roles in many cell biological processes (Le Roy and Wrana, 2005; Doherty and McMahon, 2009).

p63 has central roles in epithelial development and despite the two isoforms share some common features, TAp63 mainly acts as tumor suppressor and ΔNp63 as an oncogene.

Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has central roles in the development, physiology, and pathology of the nervous system.

The design has central role both for passive and active indoor control.

Two of the longest-serving characters in Spooks, Ruth Evershed (Nicola Walker and Harry Pearce Peter Firthth), will have central roles in the final series.

Biotin-dependent carboxylases are widely distributed in nature and have central roles in the metabolism of fatty acids, amino acids, carbohydrates, and other compounds.

HIFs have been studied intensively by the biomedical research community, because HIFs have central roles in cancer and cardiovascular disease.

In PTP1B, the residues His214, Cys215 and Ser 216 have central roles in the activation of the active-site [43].