Many years of genetic selection in dairy cattle has caused substantial allele frequency changes [ 5] that also contribute to population stratification.
The latter has caused substantial healthcare and economic burden worldwide.
Addition of 3%% charcoal has caused substantial root and shoot growth of date embryos.
Though that threat has now been lifted, Warner Bros said the unions' actions had caused "substantial damage".
But Environmental Advocates argued that it would have caused substantial harm.
Throughout human history, pathogens transmitted through feces from person to person have caused substantial mortality.
Numerous gene expression studies have shown that in some cases, perturbations can have limited effects on the magnitude of transcripts while causing substantial changes in the correlations between transcripts (e.g., [ 24]).
To investigate whether the mutation had caused any substantial changes to the active site, the crystal structure of the Y98F mutant was determined.
This activity severely affects the structure and balance of the natural ecosystem, and also has the potential to cause substantial changes in landscape geochemistry.
Antagonism of glutamate at the NMDA receptor has been shown to cause substantial changes in regional cerebral metabolic rate for glucose utilization (CMRglu) and blood flow (CBF).
