The part of the sentence "has caused many changes" is correct and usable in written English.
You can use it when you are discussing events that have led to significant changes in something. For example, "The advancement of technology has caused many changes in the way we communicate."
The growth has caused many changes to corporate operations and financial reporting.
The arrival of information and communication technologies (ICT) has caused many changes in human activities, such as teaching and learning.
Nearly 500 years of intense contact between speakers of Nahuatl and speakers of Spanish, combined with the minority status of Nahuatl and the higher prestige associated with Spanish has caused many changes in modern Nahuatl varieties, with large numbers of words borrowed from Spanish into Nahuatl, and the introduction of new syntactic constructions and grammatical categories.
Humans have caused many changes in the natural world, from introducing species from one place to another, to diverting natural watercourses, to loading that atmosphere with carbon dioxide that is producing a greenhouse effect.
The numbers suggest that the revelation of the NSA's telephone and Internet spying programs has caused many Americans to change their opinions of the national security state.
Well right now, a number of industries in China are going through bad times and this has caused many Chinese companies to change how they conduct business.
Following Guardian columnist Suzanne Moore's spat with trans activists on Twitter, the vitriol directed at trans people by Julie Burchill in the Observer has caused many to wonder how much has changed.
But the move has caused many users to voice displeasure about the changes.
This shocking realization has caused many influential scientists, including Obama advisors like Schrag, to fundamentally change their thinking about how to respond to climate change.
But they are proven to de-shock the running, jogging or high-impact forms of exercise that have caused many of us to change our exercise routine.
The new technologies, coupled with ever-increasing concerns about climate change, have caused many to reconsider nuclear energy as a potential alternative.
