The scientists believe the disappearance of amphibians has broader effects on ecosystems, particularly at the higher elevations where fewer animals can live.
Morocco's suppression of Saharawi has broader effects beyond the occupation and into the global work on climate change.
Gemcitabine has broader effects on a variety of suppressive cells, and the clinical effect seen in some studies evaluating Tregs may be partially related to the elimination of MSCs.
Recent investigations have also suggested that 5-aza has broader effects than purely as a demethylating agent, including altering activating histone modifications to repressive marks, and expression changes independent of promoter methylation (Komashko et al, 2008).
The present study with hATF shows that chemical inhibition of autophagy flux has broader effects, as it attenuates statin-induced ER stress/UPR (BIP/GRP78 and IRE α1 expression) and activation of intrinsic apoptosis (capase-9, -7 and -3).
However, it is possible that ICG-001 has broader effects than anticipated if the drug affects the ability of CBP to interact with other as-of-yet unknown co-activators.
Taken together, these observations suggest the existence of a redox signalling system that has broader effects on S-phase progression as seen by the concertedly repressed expression of all core histone genes on redox perturbation.
This leads us to the assumption that psychotherapy has broader effects in childhood than in adulthood and that vulnerability factors should be also targeted in the course of therapy in childhood.
To understand if Saw1 has broader effects in repairing different types of DNA lesions beyond its known SSA function, we examined how cells lacking Saw1 cope with several DNA damaging agents.
The altered antigen presentation most likely has broad effect on CD4+ T cell compartment, including effector populations, as has been shown for example in type 1 diabetes (Marrack and Kappler 2012, Stadinski et al., 2010).
