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The altered antigen presentation most likely has broad effect on CD4+ T cell compartment, including effector populations, as has been shown for example in type 1 diabetes (Marrack and Kappler 2012, Stadinski et al., 2010).
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Ubiquitination has broad effects on viral infections.
This suggests the Chr9p21 region has broad effects on the cardiovascular system.
Moreover, this hormone is an antioxidant and has broad effects on inflammatory cells [ 10, 11].
Therefore, stem growth habit has broad effects on plant height and maturity of soybean.
IRF5 is a transcription factor which regulates type I IFNs and has broad effects on the immune system.
With the exception of the selective immunomodulatory agents that are being explored investigationally, each of these therapies has broad effects on the immune response.
Because dietary fiber has broad effects on other causes of death, our results may reflect the success of secondary prevention in the past two decades.
Third, the ARGOS family is likely to regulate signal output from a primary rather than a peripheral element of the pathway, because modulation of ARGOS family expression has broad effects on the physiological and molecular response to ethylene.
LPA has broad effects on proliferation, survival, morphology, and differentiation in multiple neural stem/progenitor models, with distinct effects on neural stem/progenitor cells (NS/PCs) derived from different sources (Daub et al., 1997; Fukushima et al., 2000; Gschwind et al., 2002; Kue et al., 2002; Harada et al., 2004; Pebay et al., 2005; Cui and Qiao, 2006; Dottori et al., 2008).
We demonstrated that iron, a critical nutrient for T. vaginalis, has broad effects on the parasite's trancriptome, which is consistent with the observation that iron modulates trichomonad growth, metabolic fluxes, and virulence phenotypes such as cytoadherence (Mundodi et al. 2006).
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