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It has been underscored that HDAC inhibitors were able to inhibit the chaperone function of HSP90 leading to JAK2 degradation, especially in cells expressing the mutant JAK2V617F and subsequently to apoptosis.
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The role of environmental factors has been underscored by epidemiologic studies that have shown a reduction in the prevalence of stunting when members of a population where stunting is common migrate to different areas where socioeconomic status is improved.
But he declined to highlight Iran's cooperation at the talks in Bonn on fashioning a post-Taliban government, cooperation that has been underscored by the State Department.
At least since the Camp David talks of 2000, both parties have argued one line in public and another behind closed doors, an unhappy tactic that has been underscored by Al Jazeera's release of the alleged diplomatic documents.
This is an evidence-based measure that has been underscored by the Stroke Systems Work Group in California [ 9] and by the Madrid acute stroke care programme [ 12].
That point has been underscored repeatedly this week as on-the-fence lawmakers make their decisions.
That trend has been underscored by the success of PalmOne's Treo 600, which has become the favored wireless phone among Silicon Valley's digerati.
The potential for a close race has been underscored by three public opinion polls that have come out in the past week showing Mr. Corzine and Mr. Forrester both receiving under 50percentt of the vote -- although Mr. Corzine had a lead in all of them ranging from 7 to 10 percentage points.
The crucial role of this protein in the regulation of T cell function has been underscored by the discovery that Itch deficiency in humans correlates with the development of multi-system autoimmune diseases and morphologic and developmental abnormalities.
The importance of coexisting diseases has been underscored by several studies showing that COPD patients with multiple comorbidities have worse prognosis [ 4, 9– 11].
This essential role has been underscored by our recent demonstration that conditional deletion of Perp in mouse skin promotes UVB-induced skin cancer development and progression [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com