Exact(5)
More, a French RCT about hemofiltration started early (before AKI) in septic patients has been terminated prematurely for safety due to higher SOFA in the hemofiltration group in comparison with standard treatment [200].
A previous trial (Thiazolidinedione Intervention With Vitamin D Evaluation) has been terminated prematurely because of concerns on the CV safety of rosiglitazone (5).
However, a phase III study of sunitinib plus paclitaxel versus bevacizumab plus paclitaxel as first-line therapy in ABC (NCT00373256) has been terminated prematurely as it would not have met its primary goal (the primary endpoint being PFS).
Although cinaciguat has demonstrated efficacy in a proof-of-concept study in patients with acute decompensated heart failure [ 25], the phase-IIb clinical studies for the same indication has been terminated prematurely due to the high number of adverse events (mainly a significant drop of blood pressure) during acute intravenous application [ 26, 27].
17 Unfortunately, a clinical trial aimed at determining the safety, tolerability, and long-term plasma exposure over time of a one-dose regimen of four monthly subcutaneous doses of a long-acting formulation of rilpivirine (NCT00741741) has been terminated prematurely, although the results of this trial have yet to be placed in the public domain.
Similar(55)
In patients with advanced heart failure, etanercept improves systemic endothelial vasodilator capacity [ 112], although studies using anti-TNF-α antibodies in chronic heart failure have been terminated prematurely owing to a lack of benefit on the rate of death or hospitalization [ 113].
The employee has been terminated.
The newsletter has been terminated.
Robert McDonald has been terminated.
Otherwise, remote viewers would have been terminated.
Together with the sponsor, the DSMB will decide whether the trial has to be terminated prematurely.
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