As stated before, some of them have been reported individually in embryos of other plants [ 14, 15, 17, 18, 28] and, in the present work, the three features were found on proliferating cells of zygotic embryos in a different species, Brassica napus, these data support the idea that these early markers reflect a general behavior that could be exploited for other species.
Although the prognostic impacts of the Chalkley count and PAI-1 have been reported individually in large study populations, it is highly relevant to evaluate the combined prognostic impact of angiogenesis and the levels of the components of the plasminogen activator system in the same study population.
Because it has been reported that the individually expressed SUR1 subunit is sufficient for high affinity GBM binding (Aguilar-Bryan et al., 1995) and our construct has an intact SUR1 subunit, we reasoned that the reduced GBM inhibition is due to insufficient coupling between SUR1 and Kir6.2 of our fusion construct, as discussed later.
A chimeric crRNA and tracer RNA hybrid has also been designed and has been reported to be as effective as those used individually (Mali et al. 2013).
The overexpression of miR-183, miR-96 and miR-182, individually or as a cluster, has been reported in cancer [ 58], including PCa [ 59, 60].
Indeed, all of them have been reported to be individually accessible to specific antibodies [29], [34], [36], [38], [39].
Similar findings have been reported for mice individually deficient for CAR and Occludin, indicating that a number of junctional proteins might play non-redundant roles in the steady-state maintenance of TJs and barrier function (Pazirandeh et al., 2011; Saitou et al., 2000).
A review of the literature revealed that CE [15, 16], HPLC [17 21], UPLC MS/MS [22 24], LC MS/MS [25, 26] and HPTLC [27, 28] methods have been reported for the analysis of RIT, individually or in combination with other drugs.
However conflicting results, mainly derived from individually underpowered studies, have been reported [ 15- 23].
Through extensive screening in a variety of settings, several studies that have investigated the prevalence of PALB2 mutations in male breast cancer have found little evidence that PALB2 mutations are associated with increased risk of male breast cancer, 39, 49 although some individually striking pedigrees have been reported.
