A higher incidence and severity of OSD has been reported in patients who received multiple BAK-preserved medications concomitantly than in patients who were treated with only one BAK-preserved medication.
Csk has been reported to transiently migrate out of lipid rafts following TCR engagement [ 61] concomitantly with pPAG migration out of lipid rafts.
Further, we targeted histone 3 (H3) concomitantly modified at lysine-9 and serine-10 (H3K9me3/since), sitce it has been reported that phosphorylation of serine-10 is sufficient to eject heterochromatin protein 1 (HP1) bound at H3K9me3 [ 28] thus counteracting heterochromatin formation.
The intensity of reactive astrogliosis, as determined by GFAP levels, has been reported to increase in parallel with increasing progression of Braak stages in AD, while concomitantly the levels of astrocyte glutamate transporters have been reported to decline, which may raise the vulnerability of local neurons to excitotoxicity [ 221].
However, the formation of loosely mineralized deposits in dental plaque concomitantly with carious dissolution of enamel, in an environment with fluoridated mineralizing solution, has been reported.
NSAID prescriptions were slightly lower compared to a Dutch study which reported 52%% of patients receiving NSAIDs after HR or KR [ 17] and substantially lower than has been reported by an analysis of rivaroxaban clinical trials where over 70%% of patients with HR or KR concomitantly used NSAIDs [ 18].
VAN-induced nephrotoxicity has been reported to occur in 5 25% of patients [ 2, 8], although this incidence can rise to 20 35%, with a consequent increase in the severity of renal failure when VAN is administered concomitantly with aminoglycosides [ 9].
49, 52 In the Azilect post-marketing period, non-fatal cases of serotonin syndrome have been reported in subjects taking antidepressants and rasagiline concomitantly.
Only two studies assessing concomitantly both individual- and contextual-level factors in LMIC have been reported so far [ 15, 35].
The CK level that is associated with an increased risk of AKI has not been pinpointed, but values up to 5,000 U/L have been reported to increase the risk of rhabdomyolysis-induced AKI [6], especially when acidosis is present concomitantly [2, 7].
