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Apple clearly decided that it liked this concept, and since then it has been refinement after refinement after refinement.
"There has been refinement in software changes and pipe work changes to make it quieter and things like that, but the machine is running very smoothly".
Since then, there has been refinement both in terms of patient selection and supportive care.
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In recent years, most of the successful ideas in e-commerce have been refinements or variations of models that had been tried before.
The addition of ball bearings and pneumatic tires in the 1880s and of bicycle wheels in the 1890s established the present form, though there have been refinements.
In the past year there have been refinements to ENU mutagenesis approaches including balancer chromosomes and a new gene-driven approach.
There have been refinements to the basic hypothesis and to our understanding of the mechanisms involved; however, the fundamental observations remain unchanged and unchallenged.
Every development since has been a refinement of this market structure.
Running alongside this evolution has been the refinement of methods by which interfaces can be probed at scales approaching (or being at) the molecular.
As the UKCCSG has grown in size and scope of its activities, there has been continuous refinement of the organisational structure essential to its efficient management and coordination.
Chief among the recent developments in methodologic advances has been the refinement of concepts and methods for measuring individual lead dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com