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Compound 16 has been progressed to clinical development.
Conformational constraint has been used to design a potent series of α2δ ligands derived from the readily available starting material (2S,4R -hydroxy-l-proline. The ligands have improved physicochemistry and potency compared to their linear counterparts (described in our earlier publication) and the lead compound has been progressed to clinical development.
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In the perspective of therapeutic application, very few studies have been progressed to clinical trial.
More than this, other analogs, such as GS9148, GS9131, and GS7340, are also well-known anti-viral agents that have been progressed to the clinical studies for their excellent activity.
There has been progress, to be sure.
A number of investigations has been progressed related to this topic.
The work on the southbound platform has been progressing, but not in ways obvious to the casual observer.
Nigel Gray, the Highways Agency project director, said: "Work to date has been progressing well behind the scenes.
SFCLs as the devices for limiting fault currents have been progressing thanks to the development of superconducting technology.
Secondly, the TBM may have been progressing fast enough to make probe-drilling seem to be unnecessary.
The Pakistan captain had been progressing stoically, demonstrating to his colleagues that this pitch was no Mancunian minefield.
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