Sentence examples for has been problematic with from inspiring English sources
ST changes in the fetal ECG can be quantified with computational analysis, reducing subjective interpretation that has been problematic with traditional electronic fetal monitoring.
The dating of potbelly sculptures has been problematic with few of the earlier known sculptures being found in their original context.
Up to this time, the position of the Crenuchidae among characiforms has been problematic with different authors suggesting alternative phylogenetic placements [ 8, 23, 30, 32].
However, the identification of specific genes has been problematic with some genes associated with pain [ 6, 7] and others with joint structures [ 8].
The viridans group streptococci were chosen as an exemplar of electronic taxonomy using the MLSA approach since their taxonomy by traditional means has been problematic, with poorly defined species, frequent revisions and changes of species names [ 24].
However, there are two situations for which imputation has been problematic: (1) polymorphisms with low minor allele frequency (MAF), and (2) datasets where subjects are genotyped on different platforms.
Cross-species chromosome painting with chicken probes that has been so successful in identifying the homology of avian macrochromosomes has been problematic for microchromosomes, with it being difficult to obtain probes specific to individual microchromosomes by flow sorting (Griffin et al. 1999).
The issue of such forms has been problematic and difficult to deal with, particularly in relation to the evaluation and improvement of their contribution to the goals of sustainable development.
