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The RANK/RANKL pathway has been primarily implicated in metabolic, degenerative and neoplastic bone disorders or osteolysis.
DCL3 has been primarily implicated in epigenetic related phenomena and RNA-dependent DNA Methylation [reviewed by [ 48]].
In contrast, MARCO has been primarily implicated in host defense via the direct recognition and subsequent endocytosis of pathogens and the modulation of cytokine production [ 23, 24].
Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone loss via the differentiation of Th17 receptor activator of nuclear factor κB ligand (RANKL producing cells.
Of the two known FGFR ligands in worm, LET-756 has been primarily implicated in fluid balance regulation [ 24], and more recently in muscle protein degradation [ 28].
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DNA methylation has been primarily studied in the context of gene transcription and aberrant gene silencing, although it has also been implicated in the silencing of transposable elements [ 58].
"My role has been primarily blocking.
Renal tubules in insects have been primarily investigated with respect to their function in water and ion transport and several peptide hormones have been implicated in the control of diuresis [30].
In the context of object recognition, it has been suggested that the dorsal visual stream is primarily implicated in attending to objects in near space, whereas the ventral visual stream is primarily implicated in attending to objects in far space [2], [7], [8], which fits quite well with the dual visual system hypothesis [9].
SRAI is primarily implicated in homeostatic functions such as the uptake of modified lipids and proteins, in addition to having a role in pathogen clearance [ 12, 14].
Comparatively, CD16+ monocytes are primarily implicated in human atherosclerosis.
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