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This has been previously exploited for the prediction of deleterious mutations [ 17– 23].
Actually, the observation that functionally important sites tend to be evolutionary conserved has been previously exploited for the prediction of deleterious mutations [ 20].
This tool has been previously exploited to characterize and follow the fate of the Notch-responsive progenitors in the IPDs of larvae [ 16, 35].
The intrinsic fluorescence of tryptophans and coenzyme has been previously exploited to investigate structural and dynamic features of some PLP-dependent enzymes and their modification upon binding of substrates, inhibitors, and regulatory molecules [ 25– 30].
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The promoter-lacZ fusion reporter systems of several key T3SS genes, including the master regulator gene exsA, the effector genes exoS and exoT, have been previously exploited for screening and characterization of regulatory genes [26], [29].
These intensity peaks form smaller, secondary traps, which have been previously exploited and studied.
However, these capsular and antimicrobial resistance genes were relevant in this location, and such targets have been previously exploited for a similar purpose (Villa et al, 2012; Chen et al, 2014).
The synergistic effect of combining different bacteriocins has been previously studied and exploited to reduce the count of food borne and pathogenic bacteria in various applications.
It has been previously published.
In this work, we offer a computational strategy for designing synthetically feasible ligands that bind to A1R and A2AR, and inhibit PDE10A a novel multi-target combination of G protein-coupled receptors (GPCRs) and an enzyme, which has not, to our knowledge, been previously exploited.
Similar tools, e.g., structured object model [ 28], for bridging user view and the database have been previously investigated and exploited.
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