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The temporal dynamics of the cascade of events following RA-RARα-mediated chromatin activation has been mostly derived from studies on the prototypic direct RARα-target gene RARβ2.
This evidence has been mostly derived from retrospective analyses investigating ER, PgR and HER2 status in heterogeneous sites of relapse [ 1].
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In addition, it is necessary to point out that the understanding of pituitary development and the regulatory programs that control hormone expression have been mostly derived from animal experiments, in particular mice and chickens.
Alcock et al. presented an opposed view (the "insider's" view), implying that mitochondrial and plastid protein translocation machineries would have been mostly derived from existing endosymbiont bacterial transporters.
Until recently, research has been mostly focused on bone marrow-derived mesenchymal stem cells; however, other types of stem cells, including adipose-derived stem cells (ADSCs) and those derived from hair follicles gain more and more interest for potential application for the repair and regeneration of various damaged tissues.
The response has been mostly positive.
Since then, NASA has been mostly silent.
Uggla's 2011 has been mostly unlucky.
New dramas have been mostly a disaster.
Crocker: Israeli leaders have been mostly silent.
Earnings have been mostly better than expected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com