Sentence examples for has been initially demonstrated from inspiring English sources

In a general regression framework, the effectiveness of this approach has been initially demonstrated with relevant genes or subnetworks identified showing an improved association with the appropriate phenotypes.

Among the tag SNPs, rs4977574 has been initially demonstrated to be associated with risk of CAD in the Myocardial Infarction Genetics Consortium (MIGen) study [ 9].

The second mechanism by which mitochondrial Ca2+ uptake affects cytosolic Ca2+ signals has been initially demonstrated in pancreatic acinar cells, but has been also shown in neurons [27].

The potential of DWI for monitoring disease in the head and neck has been initially demonstrated in an animal model followed by promising results in patients with head and neck squamous cell carcinoma as shown in recent studies.

This has been initially demonstrated in acute promyelocytic leukemia cells, in which the recruitment of a HDAC by the PLZF-RAR fusion protein represses RAR target genes and HDACi restore the ability of retinoic acid to induce leukemia cell differentiation.

Hypermethylation of miR-124 has been initially demonstrated to occur in colon, breast and lung cancers as well as leukaemia and lymphoma (Lujambio et al, 2007) and seems to play an important role in tumour development.

Since the disease had been initially demonstrated on PET scan, FDG-PET-CT was performed again in February 2013 and demonstrated disappearance of the pathological uptake in the mediastinal lymph nodes and in the lung lesions, with reduced metabolic response in the liver (Fig.  2c, d).

Whereas the approach has been initially proposed [ 4] and rapidly implemented in animal breeding [ 5], recent empirical studies demonstrated also its potential in hybrid maize breeding [ 6- 8].

DC-specific conditional p28-deficient mice were initially demonstrated to have reduced resistance to progression of tumors such as MCA-induced fibrosarcoma and transplanted melanoma B16.

The prognostic relevance of NGS in breast cancer was initially demonstrated in 1991 [ 1] and has been validated subsequently in multiple independent studies [ 4- 14].

Video multiplexing tests were initially demonstrated without the use of any cameras.