Due to the wide dynamic range of detection and low backgrounds, LIPS has been highly informative in characterizing autoantibody levels in multiple autoimmune conditions, including patients with opportunistic infections [ 23], Sjögren's syndrome [ 24], T1D [ 25], Stiffman syndrome [ 26], myasthenia gravis [ 27] and SLE [ 28].
Decoding the activity of single, or small numbers of, neurons has been highly successful, with the best characterized example being the memory-related response of hippocampal place cells that fire invariantly when an animal is at a particular spatial location [4 6].
This metastatic neuroblastoma model has been well characterized and is highly reproducible with regard to the course of disease and organ involvement [34].
The succession of events from mitochondrial fragmentation to cell death has been well characterized and shown to be highly conserved from C. elegans to mammals [2], [3].
Knowledge bases comprise a vital component in the classic medical expert system model, yet the knowledge acquisition process by which they are created has been characterized as highly iterative and labor-intensive.
This research was conducted within the Korean educational context, one that has been characterized as highly test-intensive (Choi, 2008) in which many language teachers tend to adopt a 'teach to the test' mentality (Hwang, 2003; Koh, 2007; Li, 1998) and many students feel compelled to attend private language schools (or hakwans) to improve their English.
