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This concept has been further substantiated by recent studies in infants and young children with CF who were diagnosed by newborn screening and followed longitudinally by annual chest computed tomography (CT) and bronchoalveolar lavage (BAL) [49, 50].
This hypothesis has been further substantiated by the fact that different ER stress markers, such as GRP78 and GRP94 are overexpressed and present in amyloid containing aggregates in sIBM muscles [16], [17], most likely as a consequence of the activation of the Unfolded Protein Response (UPR).
Since its discovery, the role of AP-1 in tumorigenesis has been further substantiated.
The requirement for eIF4E hyperactivity in AKT-driven tumours has been further substantiated by recent studies.
This connection with allergy has been further substantiated with the association of a S100A7/psoriasin gene polymorphism with allergic rhinitis [ 33].
The idea has been further substantiated in studies demonstrating a direct link between H3K27me3 and PRC1 recruitment (Agger et al., 2007; Lee et al., 2007; Mujtaba et al., 2008).
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These contentions have been further substantiated by comparing ΔG°t(i) values of some selected ions in ethylene glycol water mixtures.
These findings have been further substantiated by investigation into an animal model of arthritis: knockin mice overexpressing human TNFα (hTNFtg) [ 66].
These hemostatic concerns about HES have been further substantiated by a meta-analysis of children and adults receiving HES during cardiac surgery, which showed increased blood loss in the patients receiving HES compared with albumin [ 39].
These findings, which have been further substantiated at the 20-year follow up EDIC reports, demonstrate the impact of persistent metabolic memory and the urgent need for strict glucoregulatory control in the management of diabetic patients.
The notion that 2 ml PBS has little influence is further substantiated by the assignment of profile n24h-5 thethe cluster of the controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com