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TNF484 is a TNF-alpha converting enzyme (TACE) inhibitor and has been found efficacious in experimental meningitis.
TNF484 is a novel water-soluble inhibitor of MMPs and TACE release, which is active in vitro [ 10] and has been found efficacious in experimental rat meningitis [ 9].
Fibrinogen concentrate administration has been found efficacious at reducing transfusion requirements in trauma and surgical bleeding patients, when used as a first line therapy within a goal-directed coagulation management algorithm, based on point-of-care testing [ 8, 9, 14].
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Vaccination with cell culture attenuated vvIBDV have been found efficacious (Rasool and Hussain, 2006), however, the risk for reversion to virulence (Raue et al., 2004) may hinder commercialisation.
Overall, a diversity of drugs including thalidomide [ 41], pyrazole compound 2-MBAPA [ 46], angiostatin [ 47], or antibody treatments including anti-VEGF [ 48] and anti-MAC-1 antibody for antigen CD11b [ 49] have been found efficacious in reducing microgliosis in the peptide-injection animal model of AD.
Cidofovir has been found to be efficacious in treating RRP.
The loss of statin efficacy is likely due to increased circulating PCSK9 and antibody therapy against PCSK9 has been found to be efficacious in lowering LDL-C.
Objectives: Oral budesonide has been found to be efficacious for mild to moderate Crohn's disease in adults, with equal improvement rates for budes-onide and prednisone.
Local delivery of antibiotics has been found to be efficacious in animal and human studies as an adjunct to systemic antibiotics in surgical site infection prophylaxis.
17-alpha hydroxyprogesterone caproate (17-OHP caproate) has been found to be efficacious in reducing the risk of subsequent preterm delivery in women who have had a previous spontaneous preterm birth (sPTB).
The dose of omega-3 fatty acid that has been found to be efficacious ranges from 4 to 10 g/d.
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