The phrase "has been extensively shown" is a correct and usable part of a sentence in written English.
You might use this phrase when you want to indicate that something has been demonstrated conclusively in the past. For example, "It has been extensively shown that a good night's sleep improves brain function."
Allergic asthma is characterized by a failure of immune tolerance and the development of pathologic responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation.
LysoTracker is a fluorescent dye that has been extensively shown to partition to acidified compartments within a cell, e.g. lysosomes and endosomes [38], [39], [40], [41].
Our first aim was to determine if the increases in extracellular excitatory amino acid levels is mediated by a VRAC-like pathway, as has been extensively shown in vitro.
Direct incorporation of BM-progenitor cells has been extensively shown in diverse models [24] but the low and variable frequency at which BM-progenitors are found incorporated into vessels is suggestive of an indirect (possibly paracrine or justacrine) role during the neo-angiogenesis processes.
Glial cell line-derived neurotrophic factor (GDNF), has been extensively shown to be a promising PD therapeutic that promotes the survival of dopamine neurons, protects against neurotoxin-induced injury, and has powerful restorative effects for damaged or dying dopamine neurons [2] [8].
Although, it has been extensively shown that telomeres and telomerase are involved in mammalian aging and cancer promotion and that the zebrafish is now widely used as a good model organism for assessing these complex processes [3], [4], [49], so far there have only been a few incomplete studies about telomeres and telomerase biology in this species.
Chlamydia trachomatis, Mycoplasma spp., Neisseria gonorrhoeae and Treponema pallidum have been extensively shown to be associated with infertility, particularly because of endometrial and tubal inflammation.
Microglia have been extensively shown to phagocytose Aβ [8], [9], [32].
Nevertheless, Cry1A toxins used in transgenic plants have been extensively shown to be specific against target insects and safe to non-target organisms [2] [4].
In PD, mutations within the PINK1 gene have been extensively shown to be responsible for early onset autosomal recessive disease.
Exercise stimuli have been extensively shown to modulate the heart proteome [ 94, 96– 102] which is normally followed by an improvement in aerobic capacity [ 98].
