The sentence “has been extensively increased” is a perfectly correct and usable sentence in written English.
You can use it when you want to explain that something has increased in a large or dramatic way. For example: “Over the past year, the company’s profits have been extensively increased.”.
Because Egr-1 expression has been extensively associated with increased neuronal activity (for reviews see Beckmann and Wilce 1997; O'Donovan et al. 1999), we interpret these findings as an increased activation of PPN neurons with ascending projections, and consequently, an increased synaptic drive of their target structures.
For example, posttranscriptional control of tumor necrosis factor-α (TNF-α) expression has been extensively reported, and increased expression of TNF-α, caused by impaired control of its mRNA degradation, leads to just over twofold increase in mRNA half-life which, in mouse models, causes severe autoimmune disease (7, 8, 32).
Modified atmosphere packaging (MAP) has been extensively used to increase the shelf-life of horticultural, meat and dairy products.
Nanonization has been extensively investigated to increase the oral bioavailability of hydrophobic drugs in general and antiretrovirals (ARVs) used in the therapy of the human immunodeficiency virus (HIV) infection in particular.
In recent years, the use of DeNOx catalyst on the substrate of a diesel particulate filter (DPF) has been extensively studied to increase the DeNOx functionality in a limited layout of vehicle application; the 2-way DPF/SCR is one example.
Shearing is a widely used process in the sheet metal industry and has been extensively studied to increase the understanding of the shearing mechanism, but also to improve the industrial process with respect to parameters such as tool force, tool wear and sheared surface appearance.
During the last decades, after indoor environment has been extensively analysed, interest has been increased, especially in the outdoor environment and the way it affects both the indoor environment and the overall quality of life in the cities.
As an energy carrier, hydrogen has been extensively studied to satisfy the increasing demand on green energy.
Uniconazole, a plant growth retardant, has been extensively applied in plants to increase tolerance and improve quality [ 17- 19].
Although surface water has been extensively used in various water infrastructure, increased utilization coupled with other aforementioned factors has led to an increase in the use of groundwater sources.
